Integrated management and control of space-based information system is to establish a comprehensive architecture which can manage diverse heterogeneous resources and process various complex tasks, by integrating the functions different management and control institutions of its sub-systems. First, the diversity and dynamic nature of space-based information system is analyzed. Second, a hierarchical structure of is constructed to manage and organize the diverse resources according to the order from resource to task, and a method of dynamic resource invocation is put forward to map tasks to resources and shield the diversity of users’ demands and the dynamic changes of the system. Finally, an implementation approach to integrated management and control of space-based information system is put forward to provide reference for future construction of space-based information system.